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Furoquinoline alkaloid
Furoquinoline alkaloids are a group of alkaloids with simple structure. Distribution of this group of alkaloids is essentially limited to plant family Rutaceae. The simplest member of this group is dictamnine and most widespread member is skimmianine.
A furoquinoline alkaloid, dictamnine, is very common within the family Rutaceae. It is the main alkaloid in the roots of ''Dictamnus albus'' and responsible for the mutagenicity of the drug derived from crude extracts. Dictamnine was also reported to be a phototoxic and photomutagenic compound. It participates in the severe skin phototoxicity of the plant. Another furoquinoline alkaloid, skimmianine, has strong antiacetylcholinesterase activity.
==Chemistry==
Thomas first isolated dictamnine from Rutaceae in 1923. It is very weak base, shows similar reaction with methyl iodide and dimethyl sulfate or diazomethane, does not form a derivative but go through isomerization to isodictamnine. Dictamine have linear structure which is confirmed as it forms dictamnic acid by oxidative degradation with potassium permanganate. Dieckmann cyclization followed by methylation and hydrolysis confirmed the structure of the acid. Skimmianine, another common furoquinoline alkaloid also shows a very similar type of chemistry to dictamine. Skimmianine also has a linear structure as it gave 3-ethyl-4,7,8-trimethoxy-2-quinolone from hydrolysis.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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